Indeed, insulin and IGF-1 not only stimulated TRB3 expression in human HepG2 cells in time-dependent and concentration-dependent manners by activating TRB3 transcription (Supplementary Fig. 1a–c)17, but also enhanced TRB3 expression in human colon and lung cancer cells (Supplementary Fig. 1d). The gene discussed is TRIB3; the disease is lung cancer.