We found that B16-F10 melanoma cells grew faster in diabetic KK-Ay mice than in C57 BL/6 mice, especially at the later stage after tumour-cell inoculation; the xenograft tumours from KK-Ay mice showed a higher TRB3 expression in comparison with those from C57BL/6 mice (Fig. 2b,c). Here, TRIB3 is linked to neoplasm.