CFL1 and osteoarthritis: Furthermore, Yang and colleagues proved that stimulation with cannabinoid Δ9-tetrahydrocannabinol (THC) induced the reduction of proinflammatory cytokine release by inhibiting cofilin expression in the MG-63 cell osteoarthritis model stimulated by LPS; in turn, cofilin overexpression abolished THC-induced anti-inflammation [35].