CTCF and cancer: As BORIS bound regions (2xCTSes) were highly enriched at the active promoters and enhancers in human cancer cells (Fig. 4), we analyzed the enrichment of RNAPII, H3K27ac, and H3K4me3 mapped in mouse germ cells (mouse testis, ENCODE) in correlation with BORIS-bound regions (CTCF&BORIS and BORIS-only) and CTCF-only bound regions mapped in round spermatids.