CTCFL and cancer: As clustered CTSes were strongly associated with transcription (Fig. 4) and enriched for active enhancer and promoter epigenetic marks (Figs. 4 and 5e), it was logical to hypothesize that BORIS binding and/or BORIS heterodimerization with CTCF at clustered CTSes may initiate or at least predispose cancer cells for the actual execution of a germline-like transcription program.