Next, to determine whether the hepatic mTORC1/S6K pathway is actually involved in the hypertriglyceridemia induced by hepatic SNAT2 expression, we blocked this pathway in SNAT2 mice by expressing the dominant-negative form of p70-S6kinase (DN-S6K)32 in the liver. The gene discussed is SLC38A2; the disease is hypertriglyceridemia.