The comparison between KK and KK-Ay mice indicates that suppression of the hepatic mTORC1/S6K pathway in KK-Ay mice restored obesity-related adipose LPL downregulation and serum TG elevation (Fig. 7l,m) to degrees similar to those in lean KK mice (Fig. 7l,m). This evidence concerns the gene RPS6KB1 and obesity due to melanocortin 4 receptor deficiency.