RPS6KB1 and obesity due to melanocortin 4 receptor deficiency: First, DSS administration increased plasma TG-hydrolysis activity (Fig. 8a) and salt-inhibited TG-hydrolysis activity, that is, LPL activity, by 10–15%, compared with vehicle-treated mice (Fig. 8b), to an extent similar to those in obese DN-S6K mice (Fig. 7i), leading to improvement of obesity-related hypertriglyceridemia (Fig. 8c).