By immunohistochemistry, the tumor cells were positive for Vimentin (Fig. 3c), Melan-A (Fig. 3d), melanoma-associated antigen (HMB-45) (Fig. 3e), Desmin (Fig. 3f), smooth muscle actin (SMA) (Fig. 3g), estrogen receptor (ER) (Fig. 3h), progesterone receptor (PR) (Fig. 3i) and p53, but negative for AE1/AE3 (Fig. 3j), Synaptophysin, Chromogranin A, S-100, CD38, and CD138. The gene discussed is ESR1; the disease is neoplasm.