Moreover Zhang J et al. showed that ETP-ALL cases were characterized by activating mutations in genes regulating cytokine receptor and RAS signaling, inactivating lesions disrupting haematopoietic development, and histone modifying genes (EZH2, EED, SUZ12, SETD2 and EP300) [24]. The gene discussed is SETD2; the disease is acute lymphoblastic leukemia.