Independent risk factors for new-onset AF were increasing age (HR = 1.08), male sex (HR = 1.67), C-reactive protein (HR = 1.44) [32], serum fibrinogen (HR = 1.31) [32], Left Ventricular Mass Index (HR = 1.31) [33], and Left ventricular ejection fraction (HR = 0.73) [33]. This evidence concerns the gene CRP and atrial fibrillation.