Exon 1 of the huntingtin gene followed by long polyglutamine repeats has been extensively used to study HD, because this fragment is sufficient to form intracellular aggregates, cellular toxicity, and cell death (Paulson et al, 1997; Cooper et al, 1998; Igarashi et al, 1998; Wyttenbach et al, 2001; Mochly-Rosen et al, 2014). This evidence concerns the gene HTT and Huntington disease.