Similarly, enhanced clearance of damaged mitochondria in the total extracts of HD patient-derived fibroblasts and mice striatal cells with Q111 was observed as well, as evidenced by decreased levels of mitochondrial matrix and outer membrane proteins (aconitase and Tom20), when recombinant inactive GADPH (V5 tagged) was added to organelles in the lysate (Fig 6B). This evidence concerns the gene TOMM20 and Huntington disease.