Since some DUBs might be involved in inflammasome assembly, although no direct effect of DUBs on caspase-1 activity was identified in in vitro studies [25], we tested whether chicken and human UCH-L5 can regulate pyroptosis during Salmonella infection as well as upon LPS/nigericin-triggered inflammasome activation. This evidence concerns the gene CASP1 and Salmonella Infections.