NLRP3 and Salmonella Infections: To show that b-AP15 inhibitor led to attenuation of NLRP3 inflammasome activation during Salmonella infection, we used control THP-1 cells as well as NLRP3-deficient cells (Invivogen Inc, USA), which were activated with 100 nM PMA for 24 hours and exposed to b-AP15 or DMSO (vehicle control) for 60 min.