CXCL8 and ovarian carcinoma: As shown in Figure 2, Bay 117085 significantly decreased the BZ-induced IL-8 mRNA levels (Figure 2A) and cytokine release (Figure 2B) in ovarian cancer SKOV3 and OVCAR3 cells, suggesting that IKK inhibition by Bay 117085 may enhance the BZ effectiveness in ovarian cancer treatment.