Overexpression of C/EBPβ, STAT3 or C/EBPβ + STAT3 in A172 glioma cells (that express low levels of RTVP-1), increased the promoter activity of RTVP-1 as measured by luciferase assay (Fig. 2B) and the expression of RTVP-1 (Fig. 2C), whereas, silencing of C/EBPβ, STAT3 or C/EBPβ + STAT3 in the primary GSCs HF2355 (Fig. 2D) downregulated RTVP-1 expression (Fig. 2E). Here, GLIPR1 is linked to central nervous system cancer.