Overexpression of RTVP-1 in A172 glioma cells induced a mesenchymal-like morphology (Fig. 3A), upregulated the mesenchymal markers fibronectin 1 (FN) and α-SMA (Fig. 3B) and increased cell migration of these cells (Fig. 3C–3D). This evidence concerns the gene GLIPR1 and central nervous system cancer.