Clinico-pathological factors associated with BCSS in univariate Cox analysis included pol β, FEN1, APE1, XRCC1, SMUG1, PARP1, ATR, ATM, pChk1, Chk2, p53, BRCA1, DNA-PKcs, TOPO2, Bcl-2, androgen receptor (AR), tumour stage, histological grade, tumour size, lymph-vascular invasion and lymph node status. This evidence concerns the gene APEX1 and neoplasm.