Wang et al showed that treatment of non-IL-8-expressing A2780 ovarian cancer cells with exogenous recombinant IL-8 and overexpression of cellular IL-8 induce cisplatin and paclitaxel resistance, while depleting endogenous IL-8 expression in IL-8-overexpressing SKOV-3 cells using antisense IL-8 transfection promotes the sensitivity of the cells to drugs [23]. This evidence concerns the gene CXCL8 and ovarian carcinoma.