For the downregulation of ERBB2/ERBB3 signaling pathway identified in type 2 diabetes data, nine core edges, such as “ERBB3|UBB”, “RNF41|UBB” and “ERBB2|UBB” etc. were found, and two major pathway actions (red circles in Fig. 4C) associated with type 2 diabetes were identified45, 51. This evidence concerns the gene ERBB2 and type 2 diabetes mellitus.