For the downregulation of ERBB2/ERBB3 signaling pathway identified in type 2 diabetes data, nine core edges, such as “ERBB3|UBB”, “RNF41|UBB” and “ERBB2|UBB” etc. were found, and two major pathway actions (red circles in Fig. 4C) associated with type 2 diabetes were identified45, 51. The gene discussed is RNF41; the disease is type 2 diabetes mellitus.