In the pooled group analysis including all subjects with the MYBPC3-Q1061X mutation, several metabolites, including several TGs, ether PEs and lysophospholipids were significantly correlated with indices of LV remodeling such as hypertrophy, LV mass, and systolic and diastolic dysfunction, indicating a shift in the metabolic profile with manifest hypertrophic cardiomyopathy. This evidence concerns the gene MYBPC3 and cardiac hypertrophy.