TNF and ocular melanoma: In this study, TNF-α was significantly expressed in the IHC stain and Bglap-rs1 was significantly suppressed both in qPCR analysis and the IHC stain, hence we suggest there might be a connection between up-regulation of TNF-α and down-regulation of Bglap-rs1 in the 5-FU-induced OM mouse animal model.