In this study we found CD11b and two important pro-inflammatory cytokines, IL-1β and TNF-α, and twenty-three pathways that were significantly involved in the process of 5-FU-induced OM, and some of the growth factors have been proposed to ameliorate the severity of chemotherapy-induced OM, such as EGF, G-CSF, and TGF-β. This evidence concerns the gene TGFB1 and ocular melanoma.