Since we did not study the effect of GW0742 in young and healthy animals, we do not have direct evidence that the PPAR-β/δ down-regulation associated with the underlying hypercholesteremia and atherosclerosis rather than other potentially confounding factors contributed to our findings, e.g., the use of adult swine per se, the integration of standard intensive care procedures into the experimental design, the timing and dosing of the treatment, and/or the duration of the study. This evidence concerns the gene PPARD and atherosclerosis.