ADM and Sepsis: In any case, the use of a defined anti-N-terminal antibody constitutes a novel approach to modulate the ADM pathway during the progression of sepsis, which has some obvious advantages over previously applied concepts involving ADM as a drug component: An antibody is less prone to proteolytic degradation than ADM peptide; elevated and varying proteolytic activity might in an uncontrolled manner affect peptide integrity in the circulation of sepsis patients.