PPIB and premenstrual tension: In fact, a study showed the safety and the effectiveness of physical therapy and 12,500 units of BoNT-B administered under EMG-guidance in 27 subjects suffering from PMS, for more than 3 months [20], whereas Lang evaluated the clinical safety and efficacy of 5000 U of BoNT-B under EMG-guidance in 20 patients with PMS, demonstrating a reduction of myofascial pain associated with this syndrome [21].