In this study, the activation of Wnt/β-catenin signaling by ectopic Wnt3a expression promoted VM formation and also enhanced the expressions of VEGFR2 and VE-cadherin, thereby suggesting that Wnt/β-catenin signaling may help colon cancer cells acquire a differentiation potential for endothelial cells. The gene discussed is CDH5; the disease is colonic neoplasm.