ERBB2 and breast carcinoma: In a study conducted by Latta et al, 50% to 60% of noninvasive carcinomas had HER2/neu overexpression, and given that HER2/neu overexpression in this group is associated with a higher prevalence of local relapse.20 In our study, cases of breast cancer with HER2/neu overexpression were mostly younger than age 50; however, no significant relationships were found between the 2 parameters.