TN is an extracellular oligomeric glycoprotein involved in cells’ adhesion to ECM.25 Consisting of several different structural domains such as EGFR-like repeats, TN is expressed in CNS during the process of embryogenesis.26,27 Recent research on HGGs has already revealed that TN is primarily expressed in the MAC and is inextricably with vascular proliferation, indicating that it plays a pivotal role in glimoas’ neovascularization.8–10 Zagzag et al28 have demonstrated that in human astrocytomas, TN-mRNA is highly expressed in tune with vascular proliferation. This evidence concerns the gene TNC and astrocytoma (excluding glioblastoma).