A study from the USA employed 3 apparently healthy populations suggested that −717A>G is unrelated to CRP levels, even though it is strongly associated with a decrease in CAD risk.45 Interestingly, according to Pasalic et al, −717A>G has no contributions to CRP levels in CAD patients, but an increase in the plasma level is discovered in healthy Croatian subjects with the −717G allele.14 Therefore, the biological role of −717A>G in CRP function and CAD risk remains to be elucidated. Here, CRP is linked to coronary artery disorder.