A series of clinical studies have shown that upregulated CRP serum levels result in increased likelihood to develop CAD.8,9 This observation was recently confirmed in multiple reports, where baseline CRP levels that may be affected by genetic factors were suggested to link with prognosis of cardiovascular diseases and short-term mortality.10,11 CRP levels vary substantially between individuals, which suggests an inheritable component in the regulation of serum levels. This evidence concerns the gene CRP and coronary artery disorder.