The first strength refers to the novel findings not discovered in earlier quantitative assessment, including the null association of +942G>C and CAD risk in Caucasians, and lack of a relation for −717A>G and +1444C>T. In addition, to our knowledge, this is the first study addressing the relationship between all commonly studied CRP variants and CAD risk, facilitating a more precise evaluation and a better understanding of the role of CRP in CAD. This evidence concerns the gene CRP and coronary artery disorder.