Similarly, Detaint et al. demonstrated that, in patients with chronic organic MR, high BNP levels were independently associated with worse CV outcomes and predicted atrial and ventricular remodelling but did not correlate with degree of MR [36, 37], whereas Sutton et al. showed a positive correlation of BNP, NT-pro-BNP, and ANP with severity of mitral regurgitation and left atrial dimensions [38]. This evidence concerns the gene NPPA and mitral valve insufficiency.