ACE and type 2 diabetes mellitus: For instance, up to 80% of persons with T2D also have hypertension (Savoia and Schiffrin 2007), and of those more than 65% require ≥2 medications to achieve the target blood pressure of <130/85 mmHg, with angiotensin-converting enzyme (ACE) inhibitors being the first prescribed (Sowers et al.