Similar results were also observed in other human malignancies, such as oesophageal, breast, lung, colorectal, bladder, ovarian, prostate cancers and others10, 14, 22, 23, 24, 31, 32, in which overexpression of EZH2 was often observed in more aggressive tumor subgroups and has diagnostic value. The gene discussed is EZH2; the disease is Familial prostate cancer.