In spite of advances in the development of therapies targeting proteins such as EGFR (epidermal growth factor receptor), other ErbB family members [2, 3] or c-MET [4], which are highly expressed in many SCCHN tumors, the mainstays of treatment for SCCHN remain surgery, cytotoxic chemotherapy, and radiation [5]. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.