TP53 and head and neck squamous cell carcinoma: TP53 mutations in SCCHN include frameshifts, nonsense mutations and deletions (343 out of 2022 tumors (17%); Catalogue Of Somatic Mutations In Cancer (COSMIC) [47]), and also commonly include missense mutations (870 out of 2022 tumors (43%); COSMIC [47]) that are sometimes of unknown significance, and may result in partially functional proteins [48].