PTEN and glioblastoma: As shown in Fig. 6f and g and Additional file 3: Figure S3, the luciferase activity was significantly decreased in glioblastoma cells co-transfected with 3’-UTR-PTENwt FLuci vector and miR-1908 mimic compared with those co-transfected with 3’-UTR-PTENmut FLuci vector and miR-1908 mimic, suggesting that the fragment at the 3’-UTR of the PTEN mRNA was the complementary site for the miR-1908 seed region (Fig. 6f, Additional file 3: Figure S3A and B), meanwhile silencing miR-1908 increased the luciferase activity of PTEN (Fig. 6g, Additional file 3: Figure S3C).