ERBB2 and metastasis: In the univariate analysis, HER2 positivity was significantly correlated with sex, histological type, peritoneal metastasis, hepatic metastasis, distant metastasis excluding that detected in the peritoneum, by peritoneal lavage cytology, and in the liver, depth of tumor invasion, macroscopic type, primary tumor location, size, and sample source (Fig. 2a).