Antibodies against ENO1 have been found in a variety of autoimmune and inflammatory diseases, including RA (6-66 %), systemic lupus erythematosus (19-80 %), mixed cryoglobulinemia (32-64 %), systemic sclerosis (15-30 %), anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitides (37 %), Behcet’s disease (38-45 %), autoimmune hepatitis (32-56 %), inflammatory bowel disease (10-18 %), and Hashimoto’s thyroiditis (6-83 %) [46]. Here, ENO1 is linked to systemic lupus erythematosus.