As expected, when the Shp2 protein was restored in SCSKO SCs by adenovirus infection with a constitutively active Shp2 mutant (Shp2/Q79P), the tight junction was rescued, and the electrical resistances also peaked on the third day (Fig. 3D, KO+Q79P lines). The gene discussed is PTPN11; the disease is adenoviridae infectious disease.