Yet, so far (see Table 2) no diagnosis of COF-VAP was made after the introduction of SOD/SDD, whereas the incidence of VAP per 1,000 ventilator days declined from 4.38 ± 1.64 before to 1.64 ± 0.43 (P = .007) after the introduction of SOD and SDD in our clinic [45]. This evidence concerns the gene SOD1 and ventilator-associated pneumonia.