These groups included (i) patients with GATA2 deficiency, a protean disorder of hematopoiesis, lymphatics, and immunity [6], and (ii) patients with functionally or numerically reduced alveolar macrophages and/or their respective mononuclear precursors due to CML, JMML, cALL, MDS or sideroblastic anemia in the absence of disease causing GATA2 mutations. The gene discussed is CHL1; the disease is sideroblastic anemia.