Mroczko et al. (2010)21, Wilson et al. (2012)24 and Damery et al. (2013)25 described for individuals with no neoplasia crude median MMP-9 serum concentrations of 254–361 ng/mL, inferior to the 398 ng/mL median from our cohort for this group. This evidence concerns the gene MMP9 and neoplasm.