We studied the features of the 174 adenomas included in our cohort (121 non-advanced and 53 advanced lesions) and found that the most severe characteristics such as 3 or more lesions, size ≥1 cm, and tubulovillous or villous histology corresponded to higher levels of corrected MMP-9, over 700 ng/mL. The gene discussed is MMP9; the disease is adenoma.