CHEK2 and central nervous system cancer: For example, NM_000059.3(BRCA2):c.9976A>T, p.(Lys3326Ter) (rs11571833), which increases breast and lung cancer risk,10, 37 NM_007194.3(CHEK2):c.470T>C, p.(Ile157Thr) (rs17879961), which increases breast cancer and CRC risk but decreases lung cancer risk,10, 12, 38 and NM_032043.2(BRIP1):c.139C>A, p.(Pro47Ala) (rs28903098), which has been implicated in familial breast and ovarian cancer.39 Given that such variants are a priori strong candidates for influencing the development of cancer, we examined the relationship between rs11571833, rs17879961 and rs28903098 and glioma (Table 5).