CYP4F12 and central nervous system cancer: In the combined analysis of all PAVs the strongest association for risk of glioma was provided by rs593818 responsible for the XM_006722850.1(CYP4F12):c.1117A>G, p.(Ser373Gly) amino acid change (P=1.24 × 10−5), albeit non-significant on a genome-wide basis (Supplementary Table 4).