For example, NM_000059.3(BRCA2):c.9976A>T, p.(Lys3326Ter) (rs11571833), which increases breast and lung cancer risk,10, 37 NM_007194.3(CHEK2):c.470T>C, p.(Ile157Thr) (rs17879961), which increases breast cancer and CRC risk but decreases lung cancer risk,10, 12, 38 and NM_032043.2(BRIP1):c.139C>A, p.(Pro47Ala) (rs28903098), which has been implicated in familial breast and ovarian cancer.39 Given that such variants are a priori strong candidates for influencing the development of cancer, we examined the relationship between rs11571833, rs17879961 and rs28903098 and glioma (Table 5). This evidence concerns the gene BRIP1 and lung cancer.