Of interest is NM_002168.3(IDH2):c.782G>A, p.(Arg261His) (rs118101777, non-GBM OR=3.21, P=7.7 × 10−3), which is predicted to be deleterious by CONDEL and is highly evolutionarily conserved (PhastCons=1.00, GERP=5.84). Here, IDH2 is linked to glioblastoma.