Although the association between the rare variant BRCA2:c.9976A>T, p.(Lys3326Ter) and glioma did not attain statistical significance such an assertion is supported by the established relationship between CHEK2:c.1100delC, p.(Thr367Metfs) and MUTYH:c.536A>G, p.(Tyr179Cys) and MUTYH:c.1187G>A, p.(Gly396Asp) variants which influence the risk of breast and CRC respectively.12, 13. The gene discussed is MUTYH; the disease is colorectal carcinoma.