In summary, we provide evidence that (1) FoxM1 regulates PTTG1 transcription through binding to PTTG1 promoter; (2) FoxM1 or PTTG1 knockdown attenuate colorectal cancer cell migration, invasion and metastasis; (3) FoxM1 activates PTTG1, which subsequently suppresses Wnt antagonist, DKK1. Here, DKK1 is linked to colorectal cancer.