The decreased mortality observed in our “unfavorable” ER/PR/HER2 subtypes in our elderly patients is perhaps due to better personalized treatment which, in turn, resulted in a clinical loss of distinction between “favorable” and “unfavorable” ER/PR/HER2 breast carcinoma subtypes, as we mentioned earlier as a possibility for at least HER2+ patients. This evidence concerns the gene ERBB2 and breast carcinoma.