In support of these findings, a mouse xenograft model demonstrated that pancreatic tumor tissues exposed to cigarette smoke had increased levels of α7 nAChR, pSTAT3, and MUC4; and an orthotopic mouse model demonstrated that mice exposed to cigarette smoke at both low and high concentrations had increased pancreatic tumor size and metastasis [19]. The gene discussed is MUC4; the disease is pancreatic neoplasm.