These results were consistent with those reported in a KRAS G12D mouse model of pancreatic cancer, where mice exposed to total cigarette smoke for 20 days had increased PanIN formation, and concomitantly showed an increase in the ductal marker CK19 and a decrease in the acinar marker amylase, suggesting enhanced acinar-to-ductal metaplasia [46]. This evidence concerns the gene KRAS and pancreatic neoplasm.