The APP protein, which is associated with Alzheimer’s disease, is expressed at high levels in the pancreas, can bind to α7 nAChR and has been previously shown to be increased in nicotine treated pancreatic cells across multiple species (mice, rat, and human), suggesting that it could potentially play a role in nicotine-mediated progression of pancreatic cancer, but this warrants further studies [51]. Here, CHRNA7 is linked to familial pancreatic carcinoma.