In melanoma and UVB-induced skin pigmentation, Fx inhibited tyrosinase activity and melanogenesis, whereas topical applications suppressed cyclooxygenase (COX)-2, endothelin receptor A, p75 neurotrophin receptor (NTR), prostaglandin E receptor 1 (EP1), melanocortin 1 receptor (MC1R) and tyrosinase-related protein 1 (Tyrp1) mRNA expressions [66]. The gene discussed is MC1R; the disease is melanoma.