A recent study showed that PEA-15 is expressed at higher levels in the neocortices from six-month old TgCRND8 mice, a human Alzheimer’s disease (AD) transgenic mouse model, as compared to age-matched non-transgenic mice, and PEA-15 expressing reactive astrocytes are associated with neocortical amyloid plaques in TgCRND8 mice and in postmortem human AD brains [32]. This evidence concerns the gene PEA15 and early-onset autosomal dominant Alzheimer disease.