CASP8 and breast carcinoma: In breast cancer cell line MCF-7 and HeLa cells, PEA-15 overexpression inhibits Fas ligand (FasL) and Fas/TNFα apoptotic effects by blocking the interaction between FADD and caspase-8, preventing the recruitment and activation of caspase-8 at the death-inducing signaling complex (DISC) [10].