TNFSF10 and malignant glioma: PEA-15 was also reported to protect malignant glioma cells from TNF-related apoptosis-inducing ligand (TRAIL) mediated apoptosis [12], and TRAIL resistant effect depends on both PKC [12] and CaMKII activities [34], suggesting doubly-phosphorylated PEA-15 is responsible for the anti-apoptotic effect of PEA-15.