After being adjusted for these characteristics, the results of multivariate analysis suggested that LAMP3 expression was a significant independent prediction factor for OS (HR = 1.90, 95% CI = 1.17–3.09, p = 0.010) and DFS (HR = 1.80, 95% CI = 1.18–2.74, p = 0.006) in ESCC patients (Table 2 and Table 3). The gene discussed is LAMP3; the disease is esophageal squamous cell carcinoma.