Moreover, the low p-tau and reduced p-tau to t-tau ratio were related to clinical severity as defined by the revised ALS functional rating scale (ALSFRS-R), cognitive dysfunction in mini mental state examination (MMSE) and reduction of fractional anisotropy (FA) for the corticospinal tract and corpus callosum [85]. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.