In order to test possible functional differences caused by the rs13419896 locus, we next prepared luciferase reporter constructs harboring the EPAS1 fragment encompassing the rs13419896 locus in front of the minimum promoter (Fig 1A) and performed transient transfection analyses in A549, PC-9 and HSC-2 cancer cell lines. The gene discussed is EPAS1; the disease is cancer.