EPAS1 and cancer: Among the 3 Hap-tag SNPs (rs13419896, rs4953354, and rs4953388) that were implicated to contribute to the adaptation to high-altitude hypoxia in Sherpas [22], we found binding sites and binding activities for the C/EBP-β, AP-1 or MYC family of transcription factors in a number of cancer cell types in the region of the EPAS1 rs13419896 locus within intron 1 of the gene by surveillance of ChIP-seq datasets from the ENCODE (S1 Fig).