The order of potency of adenosine agonists in the down-regulation of RGS3 in astrocytes is CGS21680>NECA>IB-MECA>CPA (Fig 4D), indicating mediation by A2A-receptors (in contrast to astrocytoma cells, where the effect is mediated by A2B receptors, see above). The gene discussed is RGS3; the disease is astrocytoma (excluding glioblastoma).