However, expression of the HMW forms of TPM1 is abolished in many transformed cell lines and carcinoma, such as in breast carcinoma cell lines [19–21], in high-metastatic Lewis lung carcinoma [22] and in tongue squamous cell carcinoma [23], whereas expression of LMW-TPM isoforms are generally not affected during oncogenic transformation [24]. The gene discussed is TPM1; the disease is breast carcinoma.