Second, the metabolic phenotype of NEXLPL+/- mice bears a greater clinical relevance in that homozygous LPL deficiency is highly uncommon in humans (1 in 1,000,000) and is characterized by a series of metabolic abnormalities including chylomicronemia, variable cognitive impairment, abdominal pain and often pancreatitis [30]. The gene discussed is LPL; the disease is Cognitive impairment.