Nowadays, the effect of diabetes on the central nervous system (CNS) is gaining importance [3]; the brain cholinergic signaling is implicated in the regulation of cytokines release [4], hepatic glucose/ glycogen production via efferent vagus nerve cholinergic output [5] and acetylcholine (ACh) facilitates the release of insulin in a glucose-dependent manner. Here, INS is linked to diabetes mellitus.