Previous studies have shown that SNPs of DNMT3b were correlated with the susceptibility of various cancers, such as hepatocellular carcinoma [19], lung cancer [18], nasopharyngeal carcinomas [20], breast cancer [7] and gastric cancer [21], and Azad et al [22] have demonstrated that DNMT3b rs2424913 polymorphism was correlated with an increased hazard risk of in head and neck cancer. This evidence concerns the gene DNMT3B and head and neck cancer.