Annotation of the HIF-1α ‘nearest-neighbor’ promoters, according to transcript class, revealed that 68% are associated with protein-coding genes, with the remainder largely associated with long non-coding RNAs (lncRNAs) and antisense RNAs (Fig 1D); proportions that are similar to those reported for HIF-1α in MCF7 breast cancer cells[39]. Here, HIF1A is linked to breast carcinoma.