Coupled to artificial overexpressed CENP-A, which results in ectopic or non-centromeric CENP-A localization [48,62], overexpression of its chaperone HJURP also correlates with disease prognosis in gliomas [101,102,103,104], although it is unknown if overexpressed HJURP drives ectopic CENP-A localization. This evidence concerns the gene CENPA and central nervous system cancer.